By Jean-Pierre Despres, Vincenzo Di Marzo
This across the world well known writer staff presents a special and thorough research and distillation of the endocannabinoid procedure and its courting to belly weight problems, diabetes, and heart problems. The endocannabinoid method (ECS) performs a big function in cardiometabolic probability, in addition to modulating power stability, feeding habit, hepatic lipogenesis, and maybe glucose homeostasis. facts means that the ECS is overactive in human weight problems and dyslipidemia. severe to the administration of cardiometabolic threat, this new, well timed ebook offers functional overviews and administration information on many very important themes, together with: belly weight problems and the metabolic syndrome the endocannabinoid process and effort stability: capabilities and dysfunctions stomach weight problems, the EC method, and cardiometabolic possibility
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Additional resources for Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk
This model implies adipose tissue RAS in the pathogenic alterations of metabolism and hypertension. There is an increasing evidence from small and large human epidemiological studies that abdominal fat may have a great implication in the link between insulin resistance and hypertension. It was reported that 1 kg increment in visceral fat predicts a 10 mmHg increase 22 ´ POIRIER AND RHEAUME Table 2 Potential Pathophysiological Pathways of Obesity/Insulin Resistance Leading to Systemic Hypertension Stimulation of the sympathetic nervous system Stimulation or renal sodium retention Decreased heart rate variability Hemodynamic effects Hypertrophy of smooth muscle by vascular or endothelial resistance in blood pressure (45).
Curr Mol Med 2005; 5:297–308. 8. Deeb SS, Zambon A, Carr MC, et al. Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J Lipid Res 2003; 44:1279–1286. 9. Despr´es JP, Ferland M, Moorjani S, et al. Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL-cholesterol in obese women. Arteriosclerosis 1989; 9:485–492. 10. Kathiresan S, Otvos JD, Sullivan LM, et al. Increase small low-density lipoprotein particle number: a prominent feature of the Metabolic Syndrome in the Framingham Heart Study.
The hypertriglyceridemia, which accompanies abdominal obesity and insulin resistance, is characterized by pronounced increase of large very-low-density lipoprotein (VLDL)1 particles that are the major determinant of plasma triglyceride levels (4). Emerging data indicate that this increase of large VLDL particles is due to excess hepatic production of VLDL particles (5). In contrast, the changes in smaller VLDL2 particles are less marked than those of VLDL1 particles. Similarly, direct hepatic secretion of VLDL2 particles is comparable in insulin-resistant and insulin-sensitive subjects.