Download Advances in Molecular and Cellular Endocrinology by Derek Leroith (Eds.) PDF

March 28, 2017 | Endocrinology Metabolism | By admin | 0 Comments

By Derek Leroith (Eds.)

Quantity 2 has all for features of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. additionally, thyroid melanoma and steroidogenic enzymes and precocious puberty are lined. eventually, the "hot themes" contain leptin and development issue signaling.

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A. (1992). Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312. C. (1995). The proline-rich region of the growth hormone receptor is essential for Jak2 phosphorylation, activation of cell proliferation and gene transcription. Mol. Endocrinol. 9, 1701-1707. , & Ailhaud, G. (1989). Growth hormone stimulates c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover. Proc. Natl. Acad. Sci. USA 86, 1148-1152.

By protecting bound hormones from clearance, they have been proposed to increase the half-life of their ligands. , 1993). The physiological role of the short PRLR isoform is more intriguing. This isoform, which is unable to activate typical PRL signaling pathways (see above), is predominant in some tissues such as liver. Determining whether the physiological role of the short PRLR is restricted to stimulation of proliferation in some cell types (O'Neal and Yu-Lee, 1994; Das and Vonderhaar, 1995) or is extended to other bioactivities is a future challenge in understanding PRLR functions.

Science 254, 821-825. A. (1991). Rational design of receptor-specific variants of human growth hormone. Proc. Natl. Acad. Sci. USA 88, 3407-3411. , & Djiane, J. (1996). Involvement of a subset of tyrosine kinases and phosphatases in regulation of the ]3-1actoglobulin gene promoter by prolactin. Mol. Cell. Endocrinol. 118, 25-35. R. (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421. K. (1995). Transduction of prolactin's (PRL) growth signal through both long and short forms of the PRL receptor.

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